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Molecular Medicine Laboratory

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Selected Publications

Inhibition of miR-25 improves cardiac contractility in the failing heart.

April 24, 2014

Nature. 2014 Apr 24;508(7497):531-5.

SUMO1-dependent modulation of SERCA2a in heart failure

September 7, 2011

Nature. 2011 Sep 7;477(7366):601-5.

Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis

April 5, 2016

J Am Coll Cardiol. 2016 Apr 5;67(13):1556-1568.

Role of the PRC2-Six1-miR-25 signaling axis in heart failure

April, 2019

J Mol Cell Cardiol. 2019 Apr;129:58-68.

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca 2+-ATPase in Heart Failure

April 26, 2019

Circ Res. 2019 Apr 26;124(9):e63-e80.

Enhancing atrial-specific gene expression using a calsequestrin cis-regulatory module 4 with a sarcolipin promoter

December, 2018

J Gene Med. 2018 Dec;20(12):e3060.

Analysis of extracellular vesicle miRNA profiles in heart failure

July, 2020

J Cell Mol Med. 2020 Jul;24(13):7214-7227.

The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling

October, 2020

J Cell Mol Med. 2020 Oct;24(20):11768-11778.

miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure

March 7, 2018

Mol Ther. 2018 Mar 7;26(3):718-729.

Cytokine-Like 1 Regulates Cardiac Fibrosis via Modulation of TGF-β Signaling

November 11, 2016

PLoS One. 2016 Nov 11;11(11):e0166480.

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Due to Phospholamban R14del Mutation

August 10, 2021

Circulation. 144(6):441-454.

EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4

May 22, 2021

Cells 2021, 10(6), 1290

Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association

October 9, 2021

Cells. 10(10):2702.

Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modeling a European cardiomyopathy with global impact

December 9, 2022

Cardiovasc Res. 118(15):3140-3150.

Matricellular protein CCN5 gene transfer ameliorates cardiac and skeletal dysfunction in mdx/utrn (+/-) haploinsufficient mice by reducing fibrosis and upregulating utrophin expression.

April 26, 2022

Front Cardiovasc Med. 9:763544.

The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function

April 27, 2022

PLos One. 17(4):e0267629.

The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB

August 2, 2022

PLoS One. 2022 Aug 2;17(8):e0269735.

Generation of Atrial-Specific Construct Using Sarcolipin Promoter-Associated CRM4 Enhancer

September 1, 2022

Methods Mol Biol. 2022;2573:115-132.

Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart

August, 2023

Circulation. 2023 Aug;148(5):405-425.

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression

August 4, 2023

Int J Mol Sci. 2023 Aug 4;24(15):12434.

Inhibition of miR-25 ameliorates cardiac and skeletal muscle dysfunction in aged mdx/utrn haploinsufficient (+/-) mice

March 28, 2024

Mol Ther Nucleic Acids. 2024 Mar 28;35(2):102174.

Conventional Method of Cardiac Ischemia/Reperfusion Injury in Mice

September 1, 2024

Methods Mol Biol. 2024:2803:111-122.

Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling

June 6, 2024

Int J Mol Sci. 2024 Jun 6;25(11):6262.

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